Runes

Runes are permanent upgrades which can be purchased with souls from the loadout menu, by clicking "Runes" in the top-left.

There are 2 rune types: Sword and Shield.

Each rune type has 4 rank rows (1+, 5+, 10+, and 15+). The 2nd, 3rd, and 4th rows are unlocked by purchasing any 5, 10, or 15 ranks respectively. You don't have to buy ranks from the row directly above a locked row (e.g. buying all 5 ranks of Power, Alacrity and Mysticism will total 15, making the final Sword row available).

You can only equip 2 runes from each row at a time: one for Sword and one for Shield (e.g. for Sword Rank 1+, you can choose only one of Power, Alacrity, or Mysticism).

Sword

Sword runes focus on dealing more damage, or inflicting status effects.

Rank	Icon	Name	Effect	Cost
1+		Power	Bullet Damage and Summon Damage multipliers +2% per rank (10% max).	1350
		Alacrity	Fire Rate and Reload Rate multipliers +2% per rank (10% max).
		Mysticism	Your bullets have a 2% chance per rank (10% max) to inflict Burn or Freeze.
5+		Aftershock	After shooting your last ammo, deal damage to all nearby enemies. This damage is equal to 20% of your Bullet Damage per rank (100% max).	3150
		Elemental Barrage	After inflicting Freeze or Burn 50 times, Fire Rate and Reload Rate multipliers +50% for 1 second per rank (5 seconds max).
		Close Combat	Enemies take 3% extra damage per rank (15% max) while within your vision range.
10+		Glass Cannon	Start the game with your HP at half of your max HP. Bullet Damage and Fire Rate multipliers +5% per rank (25% max).	6300
		Wild Magic	When enemies die while Burning or Frozen, there is a 5% chance per rank (25% max) of spreading their status effect to nearby enemies.
		Gun Glyph	Summon a Glyph every 10 seconds. After a few seconds, the Glyph explodes into 6 bullets that deal 10% damage. Reduce the time it takes to summon a Glyph by 1 second per rank (-5 seconds max). Gun Glyph's damage and cooldown are affected by Summon Damage and Summon Attack Speed multipliers. Gun Glyph does not count as a summon.
15+		Cadence	Every 3rd shot has infinite Piercing and double Bullet Size. This shot also deals +20% extra damage per rank (100% max).	12800
		Ethereal	Every 50 kills, your gun enters the Ethereal state. While Ethereal, your gun does not consume ammo. Ethereal lasts for 2 seconds per rank (10 seconds max).
		Dedication	If you have exactly 1 summon, Summon Damage and Summon Attack Speed multipliers +10% per rank (50% max).

Shield

Shield runes focus on defence and healing.

Rank	Icon	Name	Effect	Cost
1+		Vigilance	Vision Range and Pickup Range multipliers +3% per rank (15% max).	1350
		Tenacity	When your HP is at or below half of your Max HP, Fire Rate and Knockback multipliers +3% per rank (15% max).
		Courage	Knockback enemies after reloading. Reload Rate multiplier +2% per rank (10% max).
5+		Momentum	After picking up XP, Move Speed multiplier +7% (35% max) per rank for 1 second.	3150
		Agility	Dodge chance +2% per rank (+10% max). Dodge chance caps at 60%.
		Seismic Ward	Summon 2 Seismic Wards that knocks back nearby enemy every 10 seconds. Seismic Wards' ability activates 1 second faster per rank (-5 seconds max). The Seismic Wards count as 2 summons, and their cooldown is affected by Summon Attack Speed multiplier.
10+		Blessing	Start the game with Holy Shield. Reduce Holy Shield's regeneration time by 5 seconds per rank (-25 seconds max).	6300
		Healing	Every 1500th enemy killed will drop an item that heals you for 1 HP. Reduce the threshold of enemies killed needed by 100 per rank (-500 enemies max).
		Premonition	Dodge chance cap +3% per rank (+15% max).
15+		Growth	You heal 1 HP every 5th level. Increases the Experience gained from each XP orb by 4% per rank (max 20%).	12800
		Body and Soul	Every 300 seconds, gain a Soul Heart. Max 3. Increase max limit of Soul Hearts by +1 per rank (max +5).
		Wind Shield	Gain a wind shield that blocks an enemy projectile. Wind shield recharges after 10 seconds. Recharge time reduced by 1 second per rank (-5 seconds max).